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KMID : 0861020180330030045
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Korea Journal of Herbology
2018 Volume.33 No. 3 p.45 ~ p.53
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Effects of gihyeolsotong-hwan on monosodium iodoacetate-induced osteoarthritis in rats
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Xu Wen-Qiang
Kim Soon-Keun
Choi Hak-Joo
Kim Dong-Hee
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Abstract
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Objectives : In cases of osteoarthritis, the hypofunction of the cartilage and joint leads to a limited range of joint motion, swelling, and pain, which is generally treated using pharmaceutical drugs (e.g., anti-inflammatory agents, cartilage protectants, and nonsteroidal anti-inflammatory drugs) or replacement arthroplasty. However, long-term drug treatment is associated with adverse effects on the gastrointestinal systems. The present study aimed to evaluate the ability of Giheolsotong-hwan to treat of osteoarthritis symptoms in the MIA-induced rat model based on histological analysis, and factors that are associated with inflammation and bone mineral metabolism.
Methods : Giheolsotong-hwan was administered orally at doses of 200 ㎎/㎏/day or 400 ㎎/㎏/day for 2 weeks before direct injection of monosodium iodoacetate (3 ㎎/50㎕ of 0.9% saline) into the intra-articular space of the rats’ right knee. The rats subsequently received the same doses of oral Giheolsotong-hwan for another 4 weeks. We evaluated the treatment effects based on serum biomarkers and histopathological analysis of the knee joints.
Results : Compared to those in control rats, the Giheolsotong-hwan treatments significantly decreased the serum concentration of inflammation factors (i.e., IL-1β, IL-6, TNF-α, PGE2, and LTB4), and bone degrade factors (i.e., MMP-9, CTX-Ⅱ, and COMP). In addition, the Giheolsotong-hwan treatments significantly increased the concentration of glycosaminoglycans of bone defence factors, but no chage the TIMP-1. Furthermore, the Giheolsotong-hwan treatments effectively preserved the knee cartilage and proteoglycan.
Conclusion : The results indicate that Giheolsotong-hwan treated osteoarthritis symptoms. Thus, Giheolsotonghwan may be a novel oriental therapeutic option for the management of osteoarthritis.
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KEYWORD
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bone metabolism, Giheolsotong-hwan, inflammation factors, oriental therapeutic, osteoarthritis
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